Thiol-reactivity of the fungicide maneb
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منابع مشابه
Thiol-reactivity of the fungicide maneb
Maneb (MB) is a manganese-containing ethylene bis-dithiocarbamate fungicide that is implicated as an environmental risk factor for Parkinson's disease, especially in combination with paraquat (PQ). Dithiocarbamates inhibit aldehyde dehydrogenases, but the relationship of this to the combined toxicity of MB + PQ is unclear because PQ is an oxidant and MB activates Nrf2 and increases cellular GSH...
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A highly sensitive fourth derivative spectrophotometric method is presented for the residue analysis of ethylenebis dithiocarbamate fungicide Maneb. The fungicide maneb forms a blue complex with sodium molybdate on heating which is studied spectrophotometrically. The method has been successfully applied to maneb determination in wheat grains and soft drinks with high recoveries. The analytical ...
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The reactivities of the two cysteine thiol groups of calf thymus F3 histone were investigated using 5,5'-dithiobis-[2- nitrobenzoic acid], (DTNB). In isolated histone, both thiol groups were available for reaction. However, analysis of reaction profiles of native deoxyribonucleohistone, (DNH), in various solvent conditions, together with gel electrophoresis studies of DNH modified with DTNB, sh...
متن کاملEnvironmental Fate of Maneb
The fungicide maneb is moderately soluble in water and undergoes hydrolysis. Its main products for hydrolysis and photolysis are EU, ETU, EBIS, and glycine. Microbial degradation of maneb represents a minor breakdown route. Aquatic metabolism yields the main products EBIS, ETU, and EU. A field dissipation study showed that maneb persisted in soil for one week when applied at 100 ppm. Maneb is a...
متن کاملAutomated computational screening of the thiol reactivity of substituted alkenes
Electrophilic olefins can react with the S-H moiety of cysteine side chains. The formation of a covalent adduct through this mechanism can result in the inhibition of an enzyme. The reactivity of an olefin towards cysteine depends on its functional groups. In this study, 325 reactions of thiol-Michael-type additions to olefins were modeled using density functional theory. All combinations of et...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2014
ISSN: 2213-2317
DOI: 10.1016/j.redox.2014.04.007